drswapna
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24.A 52-year-old woman has long-standing rheumatoid arthritis (RA) and
is being treated with corticosteroids and nonsteroidal anti-inflammatory
drugs (NSAIDs). Which of the following cardiac complications may arise in
this clinical setting?
A. Constrictive pericarditis
B. Dilated cardiomyopathy
C. Hypersensitivity myocarditis
D. Hypertrophic cardiomyopathy
E. Restrictive cardiomyopathy
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| reet
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A.
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| sarika
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A
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| anjushree
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I THINK ANS------E
AS amyloidosis inv myocardium
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| robin082006
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B
corticosteroid long use--->Na+ and water retention---> CHF or dilated HF
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| Geroo
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I go with E
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| drk1980
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Long term steroids...complication is dilated cardiomyopathy.
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| skyhigh
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a
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| reet
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drswapna....tell the answer i m confued with the posts......
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| krsna
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dilated cardiomyopathy
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| guangyu
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answer?
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| msyamp
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LONG STANDING RA leads to amyloidosis and restricve heart. even if you then treat with steroids you cant get a dilated heart
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| Natasa
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COX inhibitors inhibits cyclooxigenase hence no PG and prostacyclin-no endothelial relaxation-coronaries deprived of O2-hipoxia-CHF in longer term course as heart is deprived of Oxygen and can not pump efficiently to meet body demands.
In case of RA-yes it should have been restrictive heart disease,but EITHER way(with or without RA and infiltratioon of myocardium) you should have dilated cardiomyopathy as a consequence.
You also get a hypertension,Coronary Ischemia as a consequence of using either non selective COX inhibitors such as ibuprofen or selective COX-2 inhibitors(which have mostly been withdrawn from US market-Bextra,Vioxx,celebrex(celecoxib group) etc.People died with CHF mostly or from a heart attack.
I HAD THIS DAMN QUESTION IN ONE OF MY PHARMACOLOGY PhD EXAMS,SO THE ABOVE POSTED IS 100 % CORRECT!
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| docarchana
Forum Guru
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long standing RA causes amyloidosis (AA) which leads to restrictive CM.
long term use of steroids causes dilated CM.
so whats the ans?
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| new_n_lost
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now i dont know whether i should base my ans according to NSAIDs role in course of Disease or the corticosteroid induced complication or Go with the RA complication itself
DCM is a Diagnosis of Exclusion way down the list but the most common cause of DCM is ischemia
i will go with E bcos RA has a relationship with both Constrictive Pericarditis n Restrictive Cardiomyopathy but more with latter
Plz give ur reasons with References plz that helps a lot
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