drswapna
Forum Senior
Topics: 52
Posts: 129
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A 32-year-old female who is 6 months pregnant presents for prenatal
care. A routine evaluation is performed, including testing for HIV
antibody. The patient is reported to be negative for RPR, but positive
for HIV antibody by the enzyme-linked immunoassay (EIA). The HIV Western
blot is positive for antibody to the p24 antigen. The patient should
be counseled
A. that she and her baby were both infected with HIV
B. that she had a false-positive HIV EIA
C. that she is negative for HIV since the RPR was negative
D. that she is positive for the HIV virus
E. to have an HIV polymerase chain reaction (PCR) test performed
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| reet
Forum Fanatic
Topics: 152
Posts: 1,411
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D.. she is HIV +
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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D
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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e
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| sarika
Forum Guru
Topics: 195
Posts: 1,200
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e
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| ed222
Forum Senior
Topics: 4
Posts: 147
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e-she needs to get a pcr to know if the baby is infected and to start antiretrovirals.
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| Natasa
Forum Elite
Topics: 9
Posts: 291
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I would go with e
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| robin082006
Forum Hero
Topics: 471
Posts: 5,125
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E for sure
In order to confirm HIV diagnosis, we need ELISA positive and Western Blot positive with at least two antigens (gp120, gp41, p24)
this patient had Western Blot positive only with one antigen, that is p24 so the diagnosis of HIV infection is not confirmatory
We need another test, that is PCR
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| elisamik
Forum Senior
Topics: 2
Posts: 39
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pcr is done only to confirm infection in fetuses, or to assess the viral load during tx.
the patient needs another western blot to confirm if she is or not infected, and the baby needs the pcr.
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| Geroo
Forum Guru
Topics: 114
Posts: 799
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answer is E
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| sturge_weber
Forum Guru
Topics: 77
Posts: 1,042
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yes its e
for western blot to be positive, u have to have 2 out of the 3 antibodies positive, in this case she has only one ab positive, hence she needs to be either retested
after 6 months and her elisa and western blot to be repeated, if then also it comes the same, then pcr...
but in this case choice e suits the most
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| krsna
Forum Senior
Topics: 1
Posts: 211
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E
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| Lim
Forum Elite
Topics: 62
Posts: 210
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PCR Amplification of the HIV Proviral DNA
Both the ELISA and Western blog suffer from the problem that antibodies may not appear in an exposed individual's blood until months after the initial exposure.
PCR amplification of the HIV proviral DNA preovides the ability to detect HIV at earlier stages of infection , because the viral nucleic acid is present immediately upon exposure, It it used to detect HIV infection in newborns whose mothers are HIV positive.
-from Kaplan Biochemistry-
i got this q wrong..you guys are gre8.
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