malinda
Forum Guru
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A pharmacy fellow is trying to determine what the plasma concentration of an experimental antiarrhythmic agent
(Drug X) will be at steady-state. A continuous intravenous infusion of the agent began 6 hours earlier at a rate of 3
mg/min. Drug X has a half-life of 3 hours, a volume of distribution of 120 L, and a clearance of 0.6 L/min. If the rate
of infusion remains constant, what will the plasma concentration be at steady-state?
A. 0.005 mg/L
B. 0.4 mg/L
C. 2.0 mg/L
D. 5.0 mg/L
E. 40.0 mg/L
F. 200.0 mg/L
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| sarika
Forum Guru
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D. 5mg/l
infusion rate = plasma concentration * CL
plasma concentration = infusion rate/Cl
= 3mg/min/.6L/min
= 5mg/l
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| robin082006
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Posts: 5,123
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agree
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