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Author15 Posts
  #1

For the past 5 months, a 51-year-old woman has noted increased swelling of her lower legs as the day progresses. She has no fever and no cough. On physical examination, she has pitting edema to the knees. A chest radiograph reveals bilateral pleural effusions, and the right heart border is prominent. Laboratory studies show a serum AST of 238 U/L, ALT 263 U/L, LDH 710 U/L, and CK 127 U/L. Which of the following underlying disease is most likely to cause these findings?

A Goodpasture syndrome
B Recurrent thromboembolism
C Renovascular hypertension
D Bronchial asthma
E Rheumatoid arthritis


  #2

is it C?

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  #3

E?

  #4

I go with E

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  #5

its not renovascular HTN or Rheumatoid arthritis....thr weren't any signs pointing towards tht if u look back.

  #6

is it goodpasure?

  #7

hey drk could u please tell n lab values for all

and then i wanna give it a try


  #8

Alanine aminotransferase (ALT), serum male 10 - 55 U/L female 7 - 30 U/L
Aspartate aminotransferase (AST), serum 14 - 59 U/L

Lactic dehydrogenase (LDH), serum 300 - 600 U/L

Creatine kinase (CK), serum female 20 - 180 U/L male 20 - 200 U/L



  #9

is it b

  #10

yup it is. how did u decide?

  #11

is it due to a right heart failure?

Edited by skyhigh on 01/24/06 - 05:43 PM

  #12

the clue was the x-ray with prominent right border leading us to think of pulmonary hypertension with consequent edema and recurrent thromboembolism. It was a good question


  #13

can someone explain how B is the ans?

  #14

Ans B. thromboembolism: right side heart hypertropy(radiograph). result in right side failure and hepatic failure resulting in high ALT and ASt values. also, right side failure is assocaited w/ pitting edema another clue. also, high LDH sign of HF.

A. Cant be possible because than she will have pnuemonitis w/ HEMOPTYSIS(hallmark). But she does not have cough. Also, rule out good pasture because GFR is normal. normal range of creatinine.


Asthma can't be right than they should give you some value about lung volume and i don't think asthma anything to do w/ lung effusion.

E. doesn't make sense at all. rhuematoid arthritis and lung effusion or right side hypertrophy don't go togather.

hope make sense


  #15

It is one of those questions which are diplayed just for filling purposes otherwise these are substandard and lacking important information .

Best of luck


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