ssrpk
Forum Fanatic
Topics: 154
Posts: 2,819
|
prostaglandins maintain the renal flow by dilating the arterioles, therefore as aspirin reduces the flow , angiotensin II comes into play in order to maintain the GFR, but again aspirin by itself is insufficient to cause renal papillary necrosis, however on top of it if u throw the free radical injury to the papilla induced by acetaminophen, tht's actually a killer combination and over time papillary necrosis occurs.
___________________
life is guud
|
| anjushree
Forum Guru
Topics: 64
Posts: 386
|
PGs are vasodilator of afferent arterioles-----inhibited by NSAIDs
angiotensin 2 are vasoconstrictor of efferent arterioles
thus in presence of NSAIDs both aff &eff are constricted
|
|
| |
| | |
