DrVirgo
Forum Hero
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Alzheimers disease affects:
-Cholinergic Neurons in Nucleus Basalis of Meynert
-Noradrenergic Neurons in the Locus Coeruleus
-Seratoninergic Neruons in the Raphe Nuclei
1. There is a decrease of Ach in Alzheimers.
2. Does Norepi. also decrease?
3. Does Seratonin also decrease?
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| ed222
Forum Senior
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Alheimer's is a disease of Ach deficiency begining in the hippocampus, cortex and N. Basalis of Meynert, then it is more broadly as disease advances. The other NTs don't change.
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| Ashley84
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There's also a degeneration of histaminergic neurons
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| ed222
Forum Senior
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Ashley can you elaborate about the degeneration of the histaminergic neurons.
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| Ashley84
Forum Newbie
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I've just read in pubmed that Alzheimer disease could be considered a disorder of neural modulation caused by the degeneration of four modulatory amine transmitter (MAT) systems, namely the serotoninergic, the noradrenergic, the histaminergic, and the cholinergic systems with ascending projections.
As regards histamine ,in post-mortem analysis of AD patients they've seen that there's a loss of histaminergic neurons present in the hypothalamus, hippocampus and temporal cortex (53%) of Alzheimer brains.
Nothing about pathologic mechanisms, only hypothesis:
1. Induction of inflammatory response throught activation of microglia
2. Ca2+ dependent cellular excito-toxicity
3. Block of neuronal transport
4. Induction of ROS
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