Geroo
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hashimoto is which type of hypersensitivity?
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| Doc2378
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Type II
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Courage does not always ROAR. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow" - Mary Anne Radmacher
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| Geroo
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are you sure?
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| Doc2378
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yeah, its an IgG antibody (inhibitory) against a receptor so type II...the same as Grave's (stimulatory) which is also type II..
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Courage does not always ROAR. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow" - Mary Anne Radmacher
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| sarika
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i think hashimoto thyroiditis is type IV delayed type hypersensitivity mediated by T lymphocytes
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| Geroo
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Doc2378 I remember goljan said it's typeII,but kaplan immunology says it's type IV as sarika said.
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| Doc2378
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Yeah, I remember that from immuno...well, I hope some else weighs in on this.. glad you raised this Geroo
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Courage does not always ROAR. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow" - Mary Anne Radmacher
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| Geroo
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check out this link.
http://teaching.path.cam.ac.uk/partIB_pract/P09/
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| Geroo
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so guys is it type II or IV ?
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| sturge_weber
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well i think it is type 4, but logically me too think it should be type 2 , non cytotoxic type
anyone???
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| mildus
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It is clear that it is not just one type but both Type 2 and Type IV HSR, but I don't know what they want us to put
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| doc179
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its noncytotoxic type 2 , kaplan immuno says its type2 and goljan says its type 2 . as graves , myasthenia gravis, hyeracute graft rejection, good pastures, autoimmuneheamolytic anemia and auto immune thrombocytic purpura and the cytotoxic type 2 is erythroblastosis fetalis
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| Geroo
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doc179 I have kaplan notes and it says it's type IV.which year is your kaplan immuno notes?
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| doc179
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I am sorry abt that I do not know which year of notes this is. But when I give it a little thought ...everywhere it says that type 4 is always cell mediated and we all know that Hashimotos is an autoimmune process so it can never be type4 . it can be either type 2 or 3. But it can not be type3 either as that is antigen antibody complex hypersensitivity
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| doc179
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well guys I went thru the goljan again for this and it says its both type 2 and type 4
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| mildus
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Hashimoto thyreoiditis is also called lymphomatose thyreoiditis and there are CD8 lymphocytes there so it is type IV as well as type II
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| krsna
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all thats fine guys but wat should v opt for in the exam??
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| docarchana
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i think answering it as type 4 is better.
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