DrVirgo
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Schizophrenia:
Increase Dopamine
Decrease Seratonin
NE?
Seratonin?
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| drk1980
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tht is increased dopamine AND serotonin.
There is no mention of NE levels as such in schizo....but with increased dopamine levels IMO its a possibility there is some conversion to NE.
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| DrVirgo
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Seratonin is responsible for "impulse control"
therefore its decreased in Schizophrenia.
(Your idea about NE could be a possibility)
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| ed222
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Excessive dopaminergic and serotonergic activity, this leading to and increase in HVA and 5HT metabolites in lab tests.
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| ed222
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Match.
1-Ach
2-DA
3-5HT
4-NE
with
a-Increase total sleep time and delta sleep
b-increase total sleep time and REM
c-decrease total sleep time and REM
d-decrease total sleep time
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| DrVirgo
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Ach -Increase REM and total sleep
DA -decrease total sleep time (because its responsible for wakefulness)
5HT-Increase total sleep time and delta sleep (?) Can you explain this?
NE -decrease REM and total sleep
*Ach is responsible for REM sleep
Its the ratio of Ach:NE
if Ach increases or NE decreases, this will lead to more REM, and vice versa.
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| ed222
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There is increase eye mov't with REM. Ach is needed for this action. As aging, Alzheimer's or both occur REM decreases. Also, Benzodiazepines decrease REM, remember GABA is inhibitory. Ach increase will lead to to increase in REM, but cecrease of NE will not because DA decreases REM too. With regards to 5HT, I don't know the exact mechanism.
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| DrVirgo
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This is according to Kaplan
The ratio of Ach: NE is the trigger for REM sleep
Also: NE pathway begins in the Pons, which regulates REM Sleep
Decrease in Norepi will INCREASE REM because in depression, there is a decrease in NE, therefore the A:N ratio will increase.
Where did you read about Dopamine and REM?
Since dopamine causes wakefulness, then it could possibly decrease REM sleep if the person awakes from REM, but I'm not sure of another mechanism... Dopamine in general affects total sleep, not really REM.
Regarding Seratonin: Helps initiate sleep and rises in first 3 hours. Thus the person goes to sleep earlier and sleeps more. Not sure how it affects delta sleep, but I know:
In depressed persons, there is a decreased seratonin, so they get less delta sleep (Stage 3 and 4)
Another Question I was wondering:
Since Parkinsons have more Ach, do they get more REM sleep?
Since Alzheimers have less Ach, do they get less REM sleep?
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| ed222
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I read in BRS behavioral sciences by Fadem
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