anjushree
Forum Guru
Topics: 64
Posts: 386
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points which i can remember
methotrexate----
antimetabolite---inhibit DHF reductase (act on Sphase )
resis---dec drug acc via inc expression of P glycoprotein
inc syn of enz,dec binding affinity of enz
special s/e----pul,renal (RP) REMB-LEUCOVORIN
USE---NHD,RA ,PSORIASIS,LEUKEMIA
6-MP------------ANTIMETABOLITE-----INHIBIT PURINE SYN
RES---REDUCED activation of prodrug
req bioactivation by HGPRT
S/E-HEPATIC
USE---ALL,CML
ALKYLATING AGENTS---Crosslink DNA strand
cyclophosphamide----req P 450 BIOTRANSFORMATION
S/E---HRP--HEPATIC,RENAL,PUL,,,,,REMB mesna
cisplatin---- s/e NN----neuro,nephro
PROCARBAZINE------FORM H2O2 -GENERATE free radical---DNA strand scission
inhibit MAO,,ENZ inv in drug metabolism
s/e----pul,neuro,
use--HD
BLEOMYCIN--------GEN free radical---DNA strand scission
act on G2
S/E---PUL
DOXORUBICIN-----intercalate bet bp
inhibit syn of DNA,RNA
INHIBIT topoisomerase 2
generate free radical----DNA strand scission
s/e CHF,,,,,,,REMB dexrazoxane
pul s/e----2B 2C MP----BLEOMYCIN,BUSULFAN,,CYCLOPHOSPHAMIDE,CARMUSTINE...METHOTREXATE,,,PROCARBAZINE
C
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| anjushree
Forum Guru
Topics: 64
Posts: 386
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I FEAR that i will forget them all ,,,,,,,i donot know that mnenomic will become long term memory or not
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| anjushree
Forum Guru
Topics: 64
Posts: 386
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plicamycin used to treat hypercalcemia
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| anjushree
Forum Guru
Topics: 64
Posts: 386
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renal s/e ----CM------cisplatin,,,methotrexate
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| anjushree
Forum Guru
Topics: 64
Posts: 386
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neurotoxic-----VCPP-----vincristine,cisplatin,procarbazine,,,pacllitaxel
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| anjushree
Forum Guru
Topics: 64
Posts: 386
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topoisomerase 2 inhibitor----etoposide,doxorubicin
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| anjushree
Forum Guru
Topics: 64
Posts: 386
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generate free radical----PBD---Procarbazine,bleomycin,,doxorubicin
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| mjl1717
Forum Hero
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I divide antimetabolites into : methotrexate, purine & pyrimidine analogs, anticancer antibotics, inhibitors of chromosomal function and misc. purine analogs-thioguanine and mercaptopurine, allopurinol increase mercaptopurine toxicity. antibiotics -dactinomycin, doxyrubicin, daunrubincin are cardiotoxic intercalating DNA. Of course lung, toxic bleomycin fragments DNA. inhibitors of chromosome function are the "vins", etoposide as you state inhibits topoisomerase Paclitaxol enhances microtubule formation.. mitotane is used in adrenocortical cancer.
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| antidepressant
Forum Guru
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good post.
mjl1717 wrote:
I divide antimetabolites into : methotrexate, purine & pyrimidine analogs, anticancer antibotics, inhibitors of chromosomal function and misc. purine analogs-thioguanine and mercaptopurine, allopurinol increase mercaptopurine toxicity. antibiotics -dactinomycin, doxyrubicin, daunrubincin are cardiotoxic intercalating DNA. Of course lung, toxic bleomycin fragments DNA. inhibitors of chromosome function are the "vins", etoposide as you state inhibits topoisomerase Paclitaxol enhances microtubule formation.. mitotane is used in adrenocortical cancer.
interesting
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| alirizvi
Forum Elite
Topics: 22
Posts: 372
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u gotta come up ways to remember them..
I remember Paclitraxel ( the p stands for polymerization so it keeps it stable ) . know vincristine and vinblastine is opposite and blastine + paclirael both supress bone marrow.
bl02mycin oxygen radical with Fe and stuff same goes for dOxOrubicin ( 02- radical )
eTOPOside - TOPOisomerase II
Azathioprine ( the post top said HGPRT but i think it might be PRPP amidotransferase just check to confirm ) --> 6MP --> uracil --> xanthine oxidase --> uric acid ..
xanthine oxidase inhibit via allopurional
do u guys know chemoman ? were u guys thought about him ? if not i can draw him tomorrow and show u guys, it makes it easier to remember the toxicities and antidotes..
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| antidepressant
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no, i dont know chemoman, i would appreciate if you can introduce chemoman, thanks.
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