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drswapna
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Topics: 52
Posts: 129

01/20/06 - 08:23 AM

A histological section of the left ventricle of a deceased 28-year-old white male shows classic contraction band necrosis of the myocardium. Biological specimens confirm the presence of cocaine and metabolites. Activity of which of the following enzymes was most likely increased in the patient's myocardial cells shortly prior to his death?
A. Phosphoenolpyruvate carboxykinase
B. Phosphofructokinase-1
C. Pyruvate dehydrogenase
D. Succinate dehydrogenase
E. Transketolase

skyhigh
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01/20/06 - 08:41 AM

guangyu
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01/20/06 - 09:02 AM

sturge_weber
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01/20/06 - 09:03 AM

pfk 1

drswapna
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01/20/06 - 11:18 AM

correct answer...can anyone explain why

doc179
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Topics: 67
Posts: 1,217

01/24/06 - 11:41 PM

just guessing. but may be this is why...the tissue is undergoing necrosis..I am assuming that anoxia exists and only glycolysis is possible, and no krebs. PFK I is the only glycolytic enzyme offered as an option.

msyamp
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Topics: 60
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01/25/06 - 02:00 AM

you are right doc. but the thing is before necrosis sets in. its during the anginal hypoxic state

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