reet
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5yr old boy, recurrent ear infections receives booster immunization against DPT. theres below normal humoral response to tetanus toxoid(tt). peripheral B& t lymphocyte counts are normal. He makes positive antibody in both passive hemaglutination & complement mediated lysis of tt-coated erythrocytes. Antibodies do not opsonize tt coated latex particles for phagocyosis & do not precipitate tt efficiently. defect is
a. affinity maturation of Ig
b. Ig isotype switching
c. somatic mutation of Ig genes
d. recombination heavy chain genes
e. recombination light chain variable region genes
plz explain ur answer too.
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| sarika
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defective class switching ans should be b
its probably hyper-igM syndrome with defect in CD40 ligand on cd4t helper cells.
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| malinda
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decreased Ig G-->I will also go with B.
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| ulise
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E
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| ulise
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WHAT IS YOUR ANSWER REET?
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| Doc2378
Forum Guru
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Hey thats from form 1..I think I marked B...
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| reet
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yes,,its B.. I too marked B
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