reet
Forum Fanatic
Topics: 152
Posts: 1,411
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cuz class I can eliminate endogenous peptides..only BUT we need to match HLA class 2 which mainly works for EXOGENOUS PEPTIDES...
this is wht i know.... waiting fr more goood explaination
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| elisamik
Forum Senior
Topics: 2
Posts: 39
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agree!
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| zziggy
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- in levinson they say that MHC II is more imporanta in allograft rejection than MHC I.
- there's a qbank quetion on the role of MHC II in acute rejection that mentions the mecanism in explication. " Class II MHC proteins are expressed on the surfaces of macrophages, dendritic cells, and B cells; this complex of molecules is recognized by CD 4+ helper T cells. The T cells of the transplant recipient recognize allogeneic MHC molecules on the surface of an antigen-presenting cell of the donor."
my 2 oppinion, please check if true:
- a little bit strange that _recipient_ Th cell recognize also _donor_ MHC II, I though that recipient Th cell react ONLY to _recipient_ MHC II.
-a kidney has both donor MHC 1 (all cells) and MHC 2 expressed (donor mesangial cells = donor APCs). If mesangial (donor macropahge cells) recognize host cells and mount a reaction agains it it may be "sort of" a graft-versus-host reaction. It is these mesangial cells that may be involved in this case.
please correct.
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