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Kaplan Qbank USMLE



Author7 Posts
  #1

man who has tyrosine negative occulocuatnaeous ALBINISM who mates with woman who has tyrosine postivie ALBINISM...What proportion of the offspring will be affected ??

0%

25%

50%

100%


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  #2

0%

both have mutations on seperate genes


  #3

can u tell where the mutations....in which chromososmes in both male and female???


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  #4

being AR the mutations are same for both male and female

Tpositive and -negative oculocutaneous albinos possess an autosomal recessive inheritance pattern. Oculocutaneous albinism results from incomplete melanization of the cellular melanosomes. In tyrosinase-negative oculocutaneous albinism, the congenital inactivity of the enzyme tyrosinase prevents the cell’s use of tyrosine in the formation of the pigment melanin. In tyrosinase-positive oculocutaneous albinism, tyrosinase activity is normal, but there is an inability of the cells to sequester the synthesized melanin into the melanosomesyrosinase-


  #5

wwooww we have a new member in our group. WELCOME NANDINI

nice explanation


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  #6

good sturge...

thanks nandini fr details


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  #7

thanks,nandinimalhar.


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