anjushree
Forum Guru
Topics: 64
Posts: 386
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How TCA preveny the action of CNS ACTING A2 AGONIST?????
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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blocking the presynaptic a2 receptor allows for the release of more NE from the postsynaptic terminal.
The TCA, mirtazapine, makes sure that the a2 receptors are blocked, so that there is no norepinephrine taken back into the synapse, rather it is released.
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| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
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mirtazapine is new drug classified as adrenergic and specific serotionin antag.
When noradrenaline and serotonin are released from nerve cells in the brain they act to lighten mood. When they are bound to nerve cells in the brain, they no longer have an effect on mood.
Mirtazapine works by blocking alpha-2 receptors that are found on nerve cells in the brain. Noradrenaline and serotonin would normally bind to these receptors. By blocking them, mirtazapine prevents noradrenaline and serotonin from becoming bound to the nerve cells. This enhances the mood-lightening effect of noradrenaline and serotonin that is released from nerve cells, and helps relieve depression.
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