sarika
Forum Guru
Topics: 195
Posts: 1,200
|
meperidine blocks M receptors leading to vasoconstriction in vessels. Maybe that has something to do with it..i am not sure though its just what came to my mind!
|
| dariush
Forum Elite
Topics: 20
Posts: 356
|
yeah i cam across this Q in Kalplan Qbook also. it does not explain clearly how. does anybody know a concrete explaination?
___________________
Allah (God) is watching over us...
|
| mjl1717
Forum Hero
Topics: 963
Posts: 5,473
|
Probably an idiosyncratic reaction. Not in Goodman and Gillman.
___________________
Smell the coffee! "Is That an Osler move??"
|
| DrPak
Forum Elite
Topics: 49
Posts: 348
|
wow... thanks for checking Goodman & Gillman. There doesn't seem to be any concept then, just donkey-memorization! I guess it's worth knowing if it came in the Qbank and is present in FA.
|
| mjl1717
Forum Hero
Topics: 963
Posts: 5,473
|
It also mentioned that multiple types of reactions could be seen such as: severe respiratory depression or excitation, delirium or hperpyrexia, convulsions. Also stating that similar interactions with MAO inhibitors were NOT seen with other opiods. What gets me is that I was under the impression that meperidine was the opiate someone would take if they did NOT want the pupillary constrition, but Goodman and Gillman contradicts this. Anyone have any info on this. "Donkey memorization" is a good play on words.
___________________
Smell the coffee! "Is That an Osler move??"
|
| DrPak
Forum Elite
Topics: 49
Posts: 348
|
Actually, that might be it. Meperidine has M-blocking action, and MAOI have adrenergic action. The two put together sort of gives you a sympathomimetic action, and if you stretch that a little further, a HTNive crisis is not unimaginable.
It's a rough sort of concept, though.
|
| infliximab
Forum Guru
Topics: 22
Posts: 320
|
hi all
i did the kaplan life lecture last year, it was said that there are 2 opiates with SSRI activity, they are :
MEPERIDINE which forms normeperidine with SSRI activity &
DEXTROMETHOPHAN
GOOD LUCK Y'ALL
|
| drk1980
Forum Guru
Topics: 147
Posts: 1,038
|
well tht shd settle tht!
also anthr weird one...procarbazine (HD drug) has MAOI activity..
|
| infliximab
Forum Guru
Topics: 22
Posts: 320
|
YES, SO I LEARNT, FROM THE FORUM OF RECENT
|
| DrPak
Forum Elite
Topics: 49
Posts: 348
|
Ah! There it is, that's the explaination!
It seems a little digging bring outs a nice logical answer to all problems. It also explain why hyperthermia and seizures occurs with dextromethorphan.
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
hi mj17171
meperidine has atropine like action so it dilates the pupils. you are right, unlike the opioids that constricts, it dilates.(cf lippincot)
i cannot find hypertensive crisis as an adverse drug intereaction when meperidine is combined with MAOI. What i find is HYPERPYRETIC coma. meperidine (or pethidine) causes HYPOTENSION.
can someone clarify this? thanks.
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
|
| |
| | | | | | | | | | | |
Similar forum topics