sturge_weber
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can someone explain chronic rejection, what plays the major role in it...????
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| sturge_weber
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anyone????
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| msyamp
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Tcells, macrophages and their mediators chronic rejection.
gradual reduction in allograft function is chronic rejection has gradual obliteration of the lumen of
small arteries in the graft caused by endothelial thickening. This response occurs more
commonly in recipients who have experienced an acute rejection.chronic rejection may be a
long-term consequence of acute rejection,
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| sturge_weber
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but like in hyperacute rejection, where we say preformed antibodies to the graft,
in chronic rejection, dont we form antibodies to slowly, against the graft....
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| msyamp
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no sturge. it is noted that there is an increased cellular lymphocytic infiltrates and
progressive intimal hypertrophy of the small to medium-sized arteries that in turn
leads to interstitial fibrosis, atrophy, and eventual failure . this is the pathology.
though there is an intense research going on on this topic they found out that it is more of cell mediated
than antibody mediated. we may not form antibodies may be because it is a cytotoxic stimulation and not t helper stimulation because of the mhc II mismatch. and more over t helpers oly go to the small number of macrophages in the kidney and fibroblast etc to take their antigen. i dont think this happens. even if happens its in significant compared to the major problem here
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| sturge_weber
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thanks msyamp u cleared my doubt
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| anjushree
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hyper acute rejection------presence of preformed Ab e.g anti-ABO Ab
Accelerated rej--------presence of presensitized cytotoxic T cell & macrophage
&ADCC
Acute rej---------primary activation of Tcell
Type 2 &4 hypersensitivity
Chronic rej-------Atherosclerosis of vascular endothelium
progressive intimal hypertrophy of small and medium sized arteries
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| anjushree
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please add more inf
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