anjushree
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Neurofibrillary tangles are intermediate filamets or microtubule associated protein????
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| mjl1717
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both?
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Smell the coffee! "Is That an Osler move??"
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| drk1980
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i'm not sure if this was a doubt or a quiz Q....anyhow googled this for you.
In Alzheimer's original description of the brain of a patient with what would become recognized as Alzheimer's disease, he noted that the internal structure of neurons were abnormal and called them neurofibrillary tangles. These abnormalities are called paired helical filaments and they consist of paired filaments that are wound around each other in a helical arrangement. The neurofibrillary tangles' primary constituent is tau protein that has six isoforms in the human brain. The tau protein is an axon-specific microtubule associated protein and seems to play a critical role in the construction of microtubules . Neurofibrillary tangles found in the brains of AD patients have hyperphosphorylated tau protein and it is thought that this process leads to a dissociation of portions of microtubules that then form into paired helical filaments in neurons.
http://www.findarticles.com/p/articles/mi_qa3690/is_200209/ai_n9112987#continue
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