DrVirgo
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Whats the most common cause of these 3 embryo wise?
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| msyamp
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ASD in downs syndrome
PDA congenital rubellwith PDA and pulmonary stenosis, fetal alcohol syndrome, maternal amphetamine use, and maternal phenytoin use.
VSD diabetes maternal, fetal alcohol syndrome, patau edward even downs
digeorge -- truncus
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| msyamp
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add more
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| DrVirgo
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thanks msyamp.
I was asking more of in what happens in the heart during embryological development.
ASD is a most commonly a secundum type defect.
VSD is due to ???
PDA is due to ???
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| zaidsuror
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VSD :is either 1)muscular :results from defect in theformation of the interventricular septum (muscular sinceit is derived from the primitive ventricles)
or 2)membraneous:resultsfrom a defect of the downward extension of the aorticopulmonary septum(right and left bulbar ridges)this explains its association withaortico pulmonary valvular problems,inaddition to its association with tetralogy of fallot and persistant truncus arteriosis.
As for PDA ,inuterine life it is patent for two reasons 1)low oxygen pressure in the bloodflowing through it ,and 2)high PGE produced by the placenta.
at normal birth these two causes a rereversed,thereby stimulating the smooth muscles lining this blood vessel to contract,hence,onstrict thevessel and close it within hours.however,in premature babies this doesn't happen ,the vessel,therefore ,doesnt close,so we create these factors bygiving oxygen and indomethacin(anti pg).
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