msyamp
Forum Fanatic
Topics: 60
Posts: 1,462
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b2 microglobulin
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| msyamp
Forum Fanatic
Topics: 60
Posts: 1,462
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multiple myeloma -- AL light chains
chronic inf -- amyloid associated protei
alzeimers - Abeta from Amyoid precursor proten
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| drk1980
Forum Guru
Topics: 147
Posts: 1,038
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also, Familial amyloidosis and senile cardiac amyloidosis- transthyretin/ prealbumin
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| sturge_weber
Forum Guru
Topics: 77
Posts: 1,042
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yes b2 microglobulin
u guys re right
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| mildus
Forum Guru
Topics: 19
Posts: 614
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dialysis for a long period - amyloid is B2 microglobulin
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| robin082006
Forum Hero
Topics: 471
Posts: 5,125
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here for review
The correct answer is C. Amyloid deposits appear similar by light and electron microscopy, but actually represent a heterogeneous population of proteins that have a common tertiary structure forming a beta-pleated sheet. Questions about the type of amyloid seen in different disease states (even though the type is usually not determined clinically) are favorites on examinations. Here are two tables to help you out:
Systemic amyloidosis: Chronic active disease AA amyloid from serum amyloid- associated (SAA) protein from liver (choice A)
Myelomas and related diseases AL amyloid from immunoglobulin light chain (choice B)
Chronic hemodialysis Beta2 microglobulin (related to high plasma levels) (choice C)
Nephropathic hereditary forms (familial Mediterranean fever): AA amyloid from SAA (choice A)
Cardiomyopathic hereditary forms (senile systemic amyloidosis) :Prealbumin/transthyretin (choice E)
Neuropathic hereditary syndromes :Prealbumin/transthyretin (choice E)
Localized amyloidosis:
Senile cardiac amyloidosis: Atrial natriuretic peptide-related fibrils
Cerebral amyloid in Alzheimer disease, Down syndrome: Cerebral amyloid in Alzheimer disease, Down syndrome
Medullary carcinoma of thyroid: Calcitonin precursors (choice D)
Isolated, massive, nodular deposits (skin, lung, urogenital tract): AL from light chains (choice B)
Edited by robin082006 on 01/14/06 - 08:46 AM
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