msyamp
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anju thats a good question. but i cant amswer this. any one?
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| reet
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it may be -when glucose phophatase is deficient---other ALTERNATE PATHWAY make ketones.
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| drk1980
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looked this up, Goljan says, due to an excess of normal glycogen in renal tubules there is decreased excretion of lactate and uric acid. hence the lactic acidosis and hyperuricemia respectively. Also lacate itself competes with uric acid for renal excretion.
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| msyamp
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so is it completly due to lactic acid excretion decrease or a high lactic acid production too?
i know it like this that due to high lactic acidosis uric acid excretion decreases
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| drk1980
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iam sure there are other mechanisms in play to increase the lactate levels......maybe one assumption i can make is that since gluconeogenesis is decreased there is a build up of the substrate lactate??
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| msyamp
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you are right. gluconeogenisis is the problem here.
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