reet
Forum Fanatic
Topics: 152
Posts: 1,411
|
also PFK 1 is rate limitng enzyme..IN glycolysis
PFK-1 inhibited by ATP and citrate. ,,,,, and activated by AMP
INSULIN ---ACTIVATE IT.
GLUCAGON--inhibit it
Edited by reet on 01/12/06 - 01:10 PM
___________________
Live as u were to die tommorow. Learn as if u were to live forever.
|
| STAYfocused
Forum Newbie
Topics: 0
Posts: 8
|
PFK-1 is the RLE in Glycolysis.
PFK-1 is regulated via 2 ways:
(1) Global (hormonal) regulation
(2) Local (energy level) regulation
(1) GLOBAL CONTROL (via indirect method involving PFK-2 and F 2,6 BisP)
Insulin => via ITK receptors/IRS/SH2 domains will activate phosphatases => DEPHOS of PFK-2 = activation. PFK-2 cataylzes the conversion of F-6P to F-2,6 BisP. F-2,6 BisP will bind? to PFK-1 thereby activating it.
Glucagon => via GS/AC/cAMP will activate PKA => PHOS of PFK-2 = inactivation.
(2) LOCAL CONTROL (via direct method)
Increase AMP levels => activate PFK-1
Increase ATP or citrate levels => inhibition of PFK-1
I got confused studying the TCA cycle because I read that ADP activates Isocitrate Dehydrogenase, why does Kaplan stress ADP there and not AMP?
|
|
| |
| | |
