msyamp
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thank you i didnt know that. i just left the intricasies of it. thanks
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| STAYfocused
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PDH complex has 3 enzymes (E1,E2,E3 --> left the names out because its LY)
step 1- Pyruvate (which contains 3-Carbons) is split into
(1) CO2 -> which is released and
(2) 2-Carbon fragment which is shuffled around
step 2- E1 transfers the 2-C fragment to TPP
step 3- E2 takes the 2-C fragment and places it on Lipoic Acid
step 4- E2 then takes the 2-C fragment from LA and places it on CoA
----- this is what gives you your Acetly-CoA, but also there are other oxidation reactions occuring
step 5- FAD oxidixes Lipoic Acid forming FADH2
step 6- then NAD oxidizes FADH2 forming NADH (which is released in the rxn)
I'm not 100% sure about steps 5 and 6. When I read it, it was more complicated then that. I don't think the boards will go into detail about this, so I just simplfied it for myself. I looked it up just so I can understand whats going on. But the order is correct, and that's how we get the pneumonic:
Tender Loving Care For Nancy
Your basically burning Pyruvate which is a 3-Carbon molecule and forming Acetly-CoA which is a 2-Carbon molecule.
Then Acetyl-CoA is burnt in the TCA cycle, and it makes sense you release only 2 CO2 because you only started with 2-Carbons.
The only questions I got on this so far on this were about the cofactors of PDH and what other enzyme needs Tendey Lovin Care For Nancy...
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