robin082006
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A five-year-old girl is brought to a pediatrician because she is developing breasts. Physical examination shows large hyperpigmented macules with irregular margins on one side of her back. Which of the following bony abnormalities would most be likely associated with these symptoms?
A.  A combination of osteitis fibrosa cystica and osteomalacia
B. .gif) A generalized thinning of bony spicules
C. Excessive bony deposition with obliteration of marrow
D. Formation of new bone beneath the periosteum of phalanges
E. Multiple localized whorls of connective tissue
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| msyamp
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it is mac cune albright syndrome
shew iwll have A osteitis fibrosa cystica. and rickets not osteo malcia.
i think generalised thinning of spicules as they have hyper cortisolism
either A or C
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| robin082006
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ha ha msyamp
you cannot choose two ans
try again
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| reet
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C ??
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| msyamp
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roin i go with A daring the consequences of a less score
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| sturge_weber
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i think its c
polyostotic fibrous displasia... hence obliteration, i think c suits it
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| skyhigh
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i think E, fibrous dysplasia
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| robin082006
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ans is E
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| msyamp
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so i got less score
but this is a good question. at least is my explanation correct?
yes fbrous dysplasia also occurs here
but is it mc albright? plz tell me
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| robin082006
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msyamp you diagnosed correctly, this is Mac Cune Albright syndrome but your choice is wrong
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| sturge_weber
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why is the ans e
multiple whorls of connective tissue, is it not mc cune albright syndrome...
where precocious puberty, and hyperpigmented macules, and fibrous dysplasia
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| robin082006
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like you at first time I didn't think about E
HERE IS THEIR EXPLANATION
The correct answer is E. McCune-Albright syndrome is the combination of precocious sexual development, irregularly shaped ("coast of Maine") pigmented skin macules, and polyostotic fibrous dysplasia. The latter condition is characterized by local bony defects containing unmineralized whorls of connective tissue.
Renal osteodystrophy refers to a constellation of bony changes occurring in the context of chronic renal failure. Features may include those of osteitis fibrosa cystica (marrow fibrosis, bony resorption and cyst formation within the marrow cavity) and osteomalacia (choice A).
Osteomalacia results from vitamin D deficiency in adults, and is characterized by a generalized thinning of bony spicules (choice B).
Osteopetrosis is characterized by excessive bony deposition that can obliterate marrow (choice C), causing anemia.
Formation of new bone beneath the periosteum of the phalanges (choice D) is characteristic of hypertrophic osteoarthropathy, which may be associated with thoracic cancer, chronic lung disease, and chronic liver disease.
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| sturge_weber
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well good one robbin
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