robin082006
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An elderly woman with a history of multiple oral ulcers presents with flaccid bullae on her scalp, face, and trunk. Manual pressure on the skin produces separation of the upper layer of the epidermis, followed by eventual sloughing of the skin. The patient has been in relatively good health until recently, and denies taking any medications. A biopsy of one of the skin lesions reveals separation of epithelial cells above the basal layer. Autoantibodies to which of the following components would most likely be found in this patient?
A.  Epidermal basement membrane proteins
B. .gif) Glycoprotein IIb/IIIa
C. Intercellular junctions of epidermal cells
D. Intrinsic factor
E. Type IV collagen
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| msyamp
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no intercellular cement defect. as in pemphigus vulgaris. supra basal
sub corneul peeling -- impetigo or pemphgus foliacious. antibodies to same intracellular cement.
impetigo you know due to inf
sub epidermal is seen in bullous pemphigoid and dermatitis herpitiformis antoboides to hemidesmosomes in bulous and to reticulin in derma herpitiformis
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| robin082006
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so your ans is....?
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| Geroo
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C
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| robin082006
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you got it
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