msyamp
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hormone senitive lipase in activated by?
1. epinephrine
2. low insulin
3. glucagon
4. gastrin
5. lipoprotein lipase
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| mazinger
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First stimulus that activates hormone sensitive lipase is low insulin levels.. In prolonged fasting epinephrine or cortisol..
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| mazinger
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well I mean overnight fasting
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| msyamp
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good
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| Natasa
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As far as I know it could be glucagon as well...
Major stimulus is epinephrine,but also can be B-corticotropin and glucagon.
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| msyamp
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noo it is low insulin and epinephrine only
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| Natasa
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"insulin inhibits lipolysis in adipose tissue while glucagon is a major activator of hormone-sensitive lipaseThe change in the insulin/glucagon ratio seen in fasting and between meals activates adipocyte lipolysis."-quote from Harper's biochemistry.
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| reet
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first ...choice would be LOW insulin
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| mildus
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hormone-sensitive lipase
1. short-term regulation (phosphorilation)
a) insulin inhibits
b) glucagon, epinephrine, norepinephrine, ACTH stimulate (via cAMP)
2. long-term regulation (induction of enzyme synthesis)
a) growth hormone, cortizol, thyreoid hormons induce synthesis of this enzyme
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| mildus
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Ganong says that hormone-sensitive lipase is stimulated by glucagon, epinephrine, norepinephrine (those three do it fast), cortisol, thyroid hormones, growth hormone (those three do it slowly). It is inhibited by insuline and PGE.
Ganong: Review of Medical Physiology, 2003
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