msyamp
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quinidine increases qt interval and prolongs prolongs qrs.
hypokalemia also prolongs qt interval.
now hyperkalemia enhances quinidine or hypokalemia enhances its effects? why?
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| msyamp
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com on guys
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| sturge_weber
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hypokalemia will enhance its effects
whereas hyperkalemia will decrease its effects
this is bcoz hyperkalemia, will cause disrupt the na k atp ase that digoxin is blocking...
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| msyamp
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no but here reverse is actually happening. hyperkalemia is enhancing its effects.
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| sturge_weber
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well ya hypokalemia hypomagnesemia, all cause digoxin toxicity
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| sturge_weber
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i think u re not right , i think hypokalemia will cause digoxin toxicity, or am i confused
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| msyamp
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ha ha sturge yu are right. HYPOKALEMIA PRECIPITATES DIGITOXICTY.
I TOO FORGOT. i AM ACTUALLY DISCUSSING QUINIDINE IN THIS QUESTION
IS HYPER OR HYPO KALEMIA THAT ENHANCES QUINIDINE?
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| sturge_weber
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haha i am so funny
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| jonathon
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Hyperkalemia usually enhances the toxicity of class I drugs whereas digoxin toxicity is enhanced by hypokalemia
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| msyamp
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AH! AT LAST . GOOD JONATHON. THANK YOU
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| DrVirgo
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Can anyone explain this mechanism that jonathan mentioned:
"Hyperkalemia usually enhances the toxicity of class I drugs whereas digoxin toxicity is enhanced by hypokalemia"
thanks. 
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| DrVirgo
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Got it!
Hyperkalemia---> ungated channel efflux slows down---> more K inside cell---> depol---> High potential for arrhythmias.
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| ramo7
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hypocalemia and digoxin
digioxin competes with k+ for binding sites on na-k+ atpase. so low k+ more digoxin to bind to the atpase thereby increasing toxicity of digoxin...i just learnt this
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