msyamp
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can any one classify these into
cardioselective
intrinsic sympathomimetic
nonselective
where they are used specifically etc
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| mjl1717
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Ill start and Ill cover the first 2. cardioselect.--metoprolol, atenolol, acebutolol, betaxalol, esmolol symp activity--pindolol, acebutolol Basically propanolol, nadalol, and timolol are non selective
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| tolito
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others with intrinsic sympathomimetic include penbutolol, carteolol, oxyprenolol. other non-selective are pindolol, alprenolol.
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| msyamp
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good. thanks. now where are they used?
ISA s
and any pther specific instances were we use
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| msyamp
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non spe a and b=labetolol,carvidelol
cardioselect. b1 --metoprolol, atenolol, acebutolol, betaxalol, esmolol
int symp activity (partial agonist) --pindolol, acebutolol
nonselective b1 and b2 -- propanolol, nadalol, and timolol are non selective
GOOD COLLECTION. BUT
I HAVE A BASIC DOUBT.
WHY ARE THESE NASTY THINGS CALLED B- BLOCKERS WHEN ACTUALLY THEY ARE DOING SOOO MANY OTHER THINGS? I HATE THEM.
JUST TO CONFUSE US.
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| mjl1717
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DO you guys agree that pindolol and alprenolol are both non selective
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| tolito
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yes pindolol and alprenolo are non selective beta blockers.
to be candid, i have not yet read how all these horrible drugs are used but i am making a table of their actions and funny behaviors.
with the ISA'S main thing is they will cause less bradycardia and hypotension cos they stimulate the sympathetic while blocking them at same time. thanks msyamp for indicating they are partial agonists. that makes sense.
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| sturge_weber
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yes pindolol and acebutolol re partial agonists
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| drk1980
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what do you do in a beta-blocker overdose state?
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| mjl1717
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glucagon
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| msyamp
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cardiac pace maker, activated charcoal with lavage and may b e atropine.
nothing much logical to do. just like symptomatic
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| mjl1717
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so beta blockers with ISA you could remember PAP-CO.. pindolol, acebutolol, penbutolol, carteolol, oxyprenolol
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| tolito
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one other thing about those with isa is the incidence of rebound Hypertension on abrupt withdrawal of the drug is less than those without ISA.
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