mjl1717
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Whats the antidote for atropine overdose ?
What would you use to reverse d-tubocurarine?
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| filiz
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Physostigmine, given as an atropine antidote by slow intravenous injection of 1 to 4 mg (0.5 to 1.0 mg in children), rapidly abolishes delirium and coma caused by large doses of atropine. Since physostigmine is rapidly destroyed, the patient may again lapse into coma after one to two hours, and repeated doses may be required. Artificial respiration with oxygen may be necessary. Ice bags and alcohol sponges help to reduce fever, especially in children.
The fatal adult dose of atropine is not known; 200 mg doses have been used and doses as high as 1000 mg have been given.
In children, 10 mg or less may be fatal. With a dose as low as 0.5 mg, undesirable minimal symptoms or responses of overdosage may occur. These increase in severity and extent with larger doses of the drug (excitement, hallucinations, delirium and coma with a dose of 10 mg or more).
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| filiz
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Neostigmine will reverse the paralysis due to d-tubocurarine . Neostigmine will
augment the paralysis produced by succinylcholine during phase I.
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