msyamp
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A 32-year-old woman develops hyperthyroidism every time she gets
pregnant. Serum T4 levels markedly increase during the first 10 weeks
of the pregnancy and then decline and are only moderately increased
during the remainder of the pregnancy. When she is not pregnant, her
thyroid hormone status is completely normal. This condition can best
be explained by a mutation in the
A. T3 receptor, rendering it responsive to progesterone
B. T3 receptor, rendering it responsive to estriol
C. TSH receptor, rendering it responsive to human chorionic gonadotropin
D. TRH receptor, rendering it responsive to human chorionic somatomammotropin
E. TSH receptor, rendering it responsive to human chorionic somatomammotropin
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| Doc2378
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C...HCG levels increase initially then decline during the second trimester
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| sturge_weber
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think c
not sure, though have done it in q bank
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| robin082006
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I think C too, by exclusion.
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| sturge_weber
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this q is just asking which hormone is increased during first ten weeks
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| msyamp
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sturge you are right
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| Zat
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Don't you think this question is also testing that both TSH & hCG are both glycoprotein hormones that have similar alfa-subunits.
Although specificity of action is rendered to the beta-subunit, in abnormally high concentrations hCG may stimulate TSH receptors. This is clinically manifested in Choriocarcinoma.
Therefore abnormality of TSH receptor would render it responsive to any of the other glycoprotein hormones; hCG, LH & FSH.
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