msyamp
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selective Ig A deficiency is the most common dysgama globulinemia.
symptoms are repeated sinopulmonary and urinogenital infections.
allegies athma and SLE and RA are more common.
Give antibiotics no immunoglobulins
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| drk1980
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tht ws good. just a point more...
the molecular defect is a failure of heavy chain gene switching. Lab evidence: normal levels of IgM and IgG; and normal levels of these Igs, ensures that some patients may not get very frequent infections. You dont give Igs or whole blood to these patients because they will develop Abs against the IgA in that product and by cross reaction deplete any IgA that they may have in their own body.
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| sturge_weber
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, a point
IGa, is presnt on the mucosal surfaces, and as a result, u will get all the mucosal infections morehence nasal and sinus infections. and gi infections
good point about Abs against iga, drk1980
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| msyamp
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giving a whole blood in these guy can cause anaplylaxix and shock.
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| sturge_weber
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| | 12/29/05 - 08:00 PM
1 of 1 forum leaders found this post helpful
| #6 |
IGa def is also presnt in ataxia telangiactesia
and we have anti Iga ab in berger s disease, which is also linked to henoch schonlein purpura
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