druas
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A 2 year -old boy with Bruton,s agammaglobulinemia has recurrent pnumonia caused by streptococcus pneumonia.Which of the following defect is the most likely cause of increased susceptibility to bacterial infections..........(Q is Not from Nmbe)
A) Leukocyte adhesion molecule defect
B)neutrophil chemotactic defect
C)neutrophil membrane associated protein defect
D)neutrophil microbicidal dafect
E)neutrophil opsonizaation defect
Edited by druas on 12/23/05 - 09:57 AM
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| skyhigh
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Bruton's Agaammaglobulinemia is a B-cell deficiency, which doesn't have circulating B cells,
and there is absence of immunoglobulins for opsonization and complement activation in B-cell deficiencies. so is the answer A?
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| druas
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sky high ...you were on the right track but lost it in the end...
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| Geroo
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I go with b
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| Doc2378
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b
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| skyhigh
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thanks druas, go with b
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| druas
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sorry again skyhigh...as i said u were on the right track...think that point again....you will find the answer
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| skyhigh
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so it's e?
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| ssrpk
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ofcourse it's E.
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life is guud
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| druas
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answer is E.Brutons is an x linked disorder characterize by faliure of pre B-cell to develop into B cells.Deficiency of IgG has an opsonization defect ,the antigen recognition site of IgG attaches to the bacteria.This facilitates the phagocytosis of bacteria by trigerring engulfment of bacteria by pseudopods and eventual formation of phagocytic vacoule.
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| Doc2378
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Good job ssrpk! ...thanks druas!
Note to myself: Revise..Revise...Revise 'Genetic Diseases' .....arrrrgh!!!!
Edited by Doc2378 on 12/23/05 - 02:46 PM
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Courage does not always ROAR. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow" - Mary Anne Radmacher
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