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Prep4USMLE Forum » USMLE Step 1 Forum » Biochemistry Forum

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4 Posts

gogetit
Forum Senior

Topics: 39
Posts: 104

12/21/05 - 07:37 AM

a man is a known heterozygous carrier of a mutation that causes hemochromatosis(autosomal recessive)..suppose that 1% of the general population consists of homozygotes for this mutation.if the man mates with somebody from the general population what is the probability that he and his mate will produce a child who is an affected homozygote??
A)0.025 B)0.045 C)0.09 D)0.10 E)0.25
can u guys solve this for me

sturge_weber
Forum Guru

Topics: 77
Posts: 1,042

12/21/05 - 08:22 AM

is it 0.045

roopashri
Forum Elite

Topics: 16
Posts: 190

12/21/05 - 09:58 AM

yah it is...

in the population, q2=0.01, so q=0.1 and p=1-q= 0.9 , and carrier 2pq=0.18 ..... when 2 carriers mate, chance of child with homozygos is 1/4 ie 0.25 ... so answer is 0.18 X 0.25=0.045

hope i am right..

robin082006
Forum Hero
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Topics: 471
Posts: 5,125

12/21/05 - 10:08 AM

excellent roopashri

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