dravedon
Forum Senior
Topics: 27
Posts: 74
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"srk2fd" wrote:
tamoxiphene
right!
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seize the day!
carpe diem!
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| jorlandoj1
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"srk2fd" wrote:
tamoxiphene
How many % of Women using tamoxiphene has endometrial cancer
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| EMI777LY
Forum Senior
Topics: 14
Posts: 135
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Effects on the Uterus-Endometrial Cancer: As with other additive hormonal therapy (estrogens), an increased incidence of endometrial cancer has been reported in association with NOLVADEX treatment. The underlying mechanism is unknown, but may be related to the estrogen-like effect of NOLVADEX. Any patients receiving or having previously received NOLVADEX who report abnormal vaginal bleeding should be promptly evaluated. Patients receiving or having previously received NOLVADEX should have routine gynecological care and they should promptly inform their physician if they experience any abnormal gynecological symptoms, eg, menstrual irregularities, abnormal vaginal bleeding, changes in vaginal discharge, or pelvic pain or pressure.
In a large randomized trial in Sweden of adjuvantNOLVADEX 40 mg/day for 2-5 years, an increased incidence of uterine cancer was noted. Twenty-three of 1,372 patients randomized to receive NOLVADEX vs. 4 of 1,357 patients randomized to the observation group developed cancer of the uterus [RR = 5.6 (1.9-16.2), p<.001]. One of the patients with cancer of the uterus who was randomized to receive NOLVADEX never took the drug. After approximately 6.8 years of follow-up in the NSABP B-14 trial, 15 of 1,419 women randomized to receive NOLVADEX 20 mg/day for 5 years developed uterine cancer and 2 of the 1,424 women randomized to receive placebo, who subsequently were treated with NOLVADEX, also developed uterine cancer. Most of the uterine cancers were diagnosed at an early stage, but deaths from uterine cancer have been reported.
In the NSABP P-1 trial, among participants randomized to NOLVADEX there was a statistically significant increase in the incidence of endometrial cancer (33 cases of invasive endometrial cancer, compared to 14 cases among participants randomized to placebo (RR=2.48, 95% CI: 1.27-4.92). This increase was primarily observed among women at least 50 years of age at the time of randomization (26 cases of invasive endometrial cancer, compared to 6 cases among participants randomized to placebo (RR=4.50, 95% CI: 1.78-13.16). Among women </= 49 years of age at the time of randomization there were 7 cases of invasive endometrial cancer, compared to 8 cases among participants randomized to placebo (RR=0.94, 95% CI: 0.28-2.89). If age at the time of diagnosis is considered, there were 4 cases of endometrial cancer among participants </= 49 randomized to NOLVADEX compared to 2 among participants randomized to placebo (RR=2.21, 95% CI: 0.4-12.0). For women >/= 50 at the time of diagnosis, there were 29 cases among participants randomized to NOLVADEX compared to 12 among women on placebo (RR=2.5, 95% CI: 1.3-4.9). The risk ratios were similar in the two groups, although fewer events occurred in younger women. Most (29 of 33 cases in the NOLVADEX group) endometrial cancers were diagnosed in symptomatic women, although 5 of 33 cases in the NOLVADEX group occurred in asymptomatic women. Among women receiving NOLVADEX the events appeared between 1 and 61 months (average=32 months) from the start of treatment.
Among participants receiving NOLVADEX, there were 33 cases of FIGO stage I [20 IA, 12 IB, and 1 IC] endometrial cancer. Among participants receiving placebo, there were 13 FIGO stage I cases [8 IA and 5 IB]. There was a single FIGO Stage IV endometrial cancer in a participant receiving placebo (See Table 3 in CLINICAL PHARMACOLOGY ). The distribution of FIGO stage was similar between participants receiving NOLVADEX and placebo. Five women receiving NOLVADEX and 1 receiving placebo with FIGO Stage IB disease received postoperative radiation therapy in addition to surgery.
Endometrial sampling did not alter the endometrial cancer detection rate compared to women who did not undergo endometrial sampling (0.6% with sampling, 0.5% without sampling) for women with an intact uterus. There are no data to suggest that routine endometrial sampling in asymptomatic women taking NOLVADEX to reduce the incidence of breast cancer would be beneficial.
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Emily
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| mjl1717
Forum Hero
Topics: 957
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Thx for the New England Medical Journal :shock:
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Smell the coffee! "Is That an Osler move??"
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| EMI777LY
Forum Senior
Topics: 14
Posts: 135
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you are welkome
It was online PDR
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Emily
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