dinesh sharma
Forum Newbie
Topics: 1
Posts: 9
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I
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| dinesh sharma
Forum Newbie
Topics: 1
Posts: 9
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If distribution of Xlinked recessive trait is 1 in 500, and the disease causes sterility in effected males then what is the carrier rate?
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| msyamp
Forum Fanatic
Topics: 60
Posts: 1,462
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Males A=normal
a=diseased
Females AA or Aa = normal
aa= diseasd
Females Frequency Males Frequency
AA p2 A p
Aa 2pq a q = 1/500
aa q2
From males, q=1/500 therefore p=499/500.
Female carriers =2pq =2 x 499/500x 1/500 =998/250000
almost 1000/250000 or 1 in 250
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| sturge_weber
Forum Guru
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yes as msyamp said. q=1/500.
so carrier frequency=2pq= 2x1/500x1=1/250
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| dinesh sharma
Forum Newbie
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Posts: 9
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I dont think so, the 2pq is derived from the fact that alleles are received from mother and father both. I think the answer should be q only i.e. 1 in 500. I heard the question from someones exam experience , so not sure about the answer.
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| msyamp
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http://employees.oneonta.edu/bachman/human%20gene...
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| zhoufg
Forum Senior
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I agree that q=1/500, 2pq=1/250. only carrier female x normal male= infertility male which is q=1/500.
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