drk1980
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Tetanus (continuous muscular excitation) is achieved in a skeletal muscle when there is sufficient free calcium available to saturate the intracellular environment and allow a greater number of cross bridges to cycle.
How does Tetany happen in HYPOcalcemic states?
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| mildus
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Calcium blockes voltage-gated sodium channels, so if there is less calcium, more sodium can go into the cell, and if there is more calcium it doesn't allow action potential to happen by blockage of sodium channels
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| drk1980
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thanks a lot, mildus!
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| Stan
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is important to know. thanks mildus
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| msyamp
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so in hypercalcemic state there is increased ltime of muscle contraction and in hypocalcemic states there is hyperexcitablity. is that rigth?
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| mildus
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hypercalcemia - blockes sodium channels, so decreases excitability
hypocalcemia - less calcium, so less blockage of sodium channels, so sodium can enter the cell very easily, i.e. increased excitability
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| sturge_weber
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good explanation mildus
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| RayBerg
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Let's talk about blockage of sodium channels. When we're referring to hypercalcemia, we're referring to excess/high calcium concentration in the blood (i.e. extracellular) is that correct?
If so, the blockage of Na channels must be occuring on the extracellular surface by calcium. Is that correct? Thanks in advance...
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| mildus
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Hypercalcemia - increased extracellular (plasma and interstitial) calcium concentration
The blockage of Na channels occures on the extracellular surface by calcium.
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