sturge_weber
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does the vasopressin act on the v2 receptors via the camp Gs pathway, or via the phospholipase c pathway, kaplan biochem says phospholipase c
but q bank says camp pathway
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| reet
Forum Fanatic
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 VASSOPRESIN Gq- via phospolipase C pathway
no idea about Gs /cAMP?? ?
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| cyra
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V1 acts via Gq/PLC
V2 acts via Gs/cAMP
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| reet
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oh good!!!!it means VASSOPRESSIN has two types of RECEPTORS V1 and V2? can ANY one explain where they lie, (same location)??
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| sturge_weber
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let me tell u,
vasopressin acts on 4 receptors, V1a, V1b, V2, oxytocin receptor
V2 is the one of our interest, it is present in the renal medullary segment of collecting ducts...it acts via the camp pathway, increases protein kinase a and this further increases the expression of aquaporins2 aqp2, the water channel...
the V1a is present on the vessels, Vib is present in the anterior pitutary and regulates the secretion of acth, and along with the oxytocin receptor, increases the phospholipasec and acts via this pathway
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| zzpearl
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V1 acts via Gq/PLC
V2 acts via Gs/cAMP
correct, see FA and BRS
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| ujaala
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yes tht is rite , u can check it out in FA.. biochem section...
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| reet
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thanks sturge
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