| Author | 13 Posts |
karusmle
Forum Guru
Topics: 295
Posts: 1,000
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I THINK GENETICS WAS HARD ENOUGH IN THE NBME , MAY BE FOE ME , DO U REMEMBER A QUESTION , WHERE THEY ASKED
GRANFATHER HAS THE DISEASE , HUNTINGTONS AND THE SON DOES NOT HAVE IT AND WHAT IS THE CHANCE FOR THE GRANDDAUGTER TO GET THE DIEASE ???
I THINK THE ANSEWR CHOICES WERE
A.LESSS THAN 1 %
b.25%
c.50%
d.10%
and i dont remember the rest of the choices
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| karusmle
Forum Guru
Topics: 295
Posts: 1,000
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one more question
v <---->w -4.0
w <----->x +0.4
x<------>y -3.4
y <-----> Z +5.7
which is increased in amount at equlibirium??
A.V
B.W
C.Y
D.X
E.Z
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| karusmle
Forum Guru
Topics: 295
Posts: 1,000
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DO U REMEMBER A QUESTION WERE THEY SHOWED A CROSS SECTION AT T 9 /T 10 SECTION AND ASKING FOR WHICH ORGAN HAS THE NEOPLASIA WERE THE WOMEN HAD SYMPTOMS OF HEART POUNDING UPON BLOOD AND CLAMMY SKIN WITH LATER DEVELOPING HYPERTENSION???
WHICH ONE DID U SELECT AND PLEASE THE PUT DOWN THAT QUESTION FOR DISCUSSION IF U HAVE
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| karusmle
Forum Guru
Topics: 295
Posts: 1,000
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DO U REMEMBER THE QUESTION THAT WAS ASKED THE IMMUNOGENECITY OF THE VACCINE WAS INCREASED WITH THE PROTEIN CONJUGATION AND ABOUT THE TENATANUS TOXOID VACCINE ADMINISTRATING AND THE IMMUNOCOMPRIMISED STATUS IS FOUND OUT , I DONT REMEMBER IT EXACTLY , IF U HAVE THAT QUESTION PLEASE DO PUT IT FOR DISCUSSION........
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| zzpearl
Forum Senior
Topics: 52
Posts: 142
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To Karusmle,
1. There is a Q : GRANFATHER HAS THE DISEASE ,familiar Hyperlipidemia, autosome dominant, AND THE SON DOES NOT HAVE been tested. WHAT IS THE CHANCE FOR THE GRANDDAUGTER TO GET THE DIEASE through the son ?<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
I chose 25%, because there is 50% chance the son will get the autosome dominant allele from GRANFATHER, and 50% chance pass to his daughter.
2. I chose C:Y. because there is biggest energy obstacle to overcome from Y to Z, +5.7.
3. I chose the answer which represents Adrenal gland. Sorry, I do not have this particular Q. But it is pretty obvious, a triangle-like tissue close to kidney.
4. I chose: defect in Ig isotype switch. Since the Ig the boy made can mediate complement activation, but can not facilitate opsonization. So his Ig is IgM , can not be switched into IgG.
Hope this helps. 
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| karusmle
Forum Guru
Topics: 295
Posts: 1,000
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THANK U ZZPEARL.,I THINK I WENT WENT WRONG IN THE LAST TWO ANSWERS WHAT U GAVE,I KNOW THE CONCEPT BUT SOMEHOW OR THE OTHER IT IS NOT STRICKING ME IN THE EXAM , MAY BE I M TENSED ,
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,819
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huntington's is autosoal dominant, and if the son has'nt got the diseased allele how can he transmit one to the granddaughter.... answer is 0
#2-agree with zzpearl answer, but this how it goes, the last two reactions, both favours production of Y ,although at one place it is a recatant and product at the other.
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life is guud
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| zzpearl
Forum Senior
Topics: 52
Posts: 142
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I agree with SSRPK if the Q described like this: "the son has'nt got the disease". But I clearly remember the Q stem is " the son has not been tested" . So he still have 50% got the allel. 
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| karusmle
Forum Guru
Topics: 295
Posts: 1,000
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yes , i do remember like what zzpearl said , zzpearl , do u remember a question with positive correlation graph of weight and height and they just gave the value i think the choices were
a.+1.0
b.+0.6
c.-1
d.-0.6
e.0
since it was a positive correlation grach i thought the first two choices ,but i dont know which one is the best and how to approach this question
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| aonty
Forum Senior
Topics: 21
Posts: 119
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well i guess it works like this
in autosomal dominant half of the kids will have the genes tat meansif the gradfather had 2 kids one will hav ethe gene while the other will be phenotypically normal
tat makes the father a 50%candidate for acquiring the disease phenotypically but as he has not been tested so not sure if he has it or not
so this dereases the chances further for the grandson to have the disease making it down to 25%
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| tn1kinobe
Forum Newbie
Topics: 0
Posts: 21
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karusmle wrote:
DO U REMEMBER A QUESTION WERE THEY SHOWED A CROSS SECTION AT T 9 /T 10 SECTION AND ASKING FOR WHICH ORGAN HAS THE NEOPLASIA WERE THE WOMEN HAD SYMPTOMS OF HEART POUNDING UPON BLOOD AND CLAMMY SKIN WITH LATER DEVELOPING HYPERTENSION???
WHICH ONE DID U SELECT AND PLEASE THE PUT DOWN THAT QUESTION FOR DISCUSSION IF U HAVE
Yeah, i did.. it's a neoplasm of the adrenal gland causing pheochromocytoma... Choose E) on the picture of the cross-section..
http://www.prep4usmle.com/forum/comments.php?id=3...
PEACE!!!
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| blueocean
Forum Senior
Topics: 15
Posts: 195
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If the son does not have the disease the risk for the grandaughter is 0; if the son had not been tested yet the risk for the son is 1/2 and for the grandaughter 1/4.
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| blueocean
Forum Senior
Topics: 15
Posts: 195
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http://www.prep4usmle.com/forum/thread/39821
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