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NBME Q Pharm

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8 Posts

zzpearl
Forum Senior

Topics: 51
Posts: 138

12/05/05 - 07:09 PM

1. Which drug for maintenance therapy in patient w/ moderate to severe asthma also has positive cardiac inotropic effects, vasodialtion, diuretic and stimulate diaphragmatic contraction?

A Atropine

B Beclomethasone

C Dextromethorphan

D propranolol

E Theophylline

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I chose E using Exclusion method, But not sure whether E has these characteristics.

2. A neonate with swelling neck has decreased T4 and increased TSH. Which drug chronically ingested by mom during the pregnancy?

A Corticosteroids

B Propranolol

C Propythiouracil

D T4

<?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" />E T3

I chose C, But Propythiouracil is safe to use in pregnancy. confused

aonty
Forum Senior
avatar

Topics: 21
Posts: 119

12/05/05 - 07:16 PM

question 2 ans is c

karusmle
Forum Guru

Topics: 295
Posts: 998

12/05/05 - 07:22 PM

why the answer in the question 2 be D?

Reddoc
Forum Senior
avatar

Topics: 2
Posts: 109

12/05/05 - 07:37 PM

1 - E theophylline

2-c is right. Propylthiouracil is the best drug in preg in comparision to the others , but extension of its pharmacological actions will produce hypothyr symptoms in the neonate, and resultant increase in TSH. Ans cant be D cos T4 would produce a suppression of TSH in the baby, not an increase like the Q says.

I better b right in both- I have my exam next Friday shocked

dharjma
Forum Senior

Topics: 11
Posts: 182

12/06/05 - 04:39 AM

hey i thought T3 increase by mother will cause failure of thyroid gland to develope in baby. and i think t3 is the active form that provides feedback to gland. id go with E.

tn1kinobe
Forum Newbie

Topics: 0
Posts: 21

09/14/06 - 12:34 AM

dharjma wrote:
hey i thought T3 increase by mother will cause failure of thyroid gland to develope in baby. and i think t3 is the active form that provides feedback to gland. id go with E.

You are right... PTU cannot cross placenta, so it's safe in pregnancy. T3 will suppress thyroid development in neonate.

kingdavid26
Forum Newbie

Topics: 0
Posts: 6

10/02/06 - 01:14 AM

T4 is active form in negative feedback though.

sandra
Forum Guru

Topics: 200
Posts: 468

10/02/06 - 07:14 AM

prylthiouracil does crossthe placenta and causes hypothyroidism in infant...

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