robin082006
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What is the machenism for the use of diuretic for this dz?
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| robin082006
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no reply?
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| drk1980
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N.D.I is an inability of Vasopressin2(V2) receptors to respond to ADH in teh collecting ducts.
What thiazide does is, prevents reabsorption(in distal tubule) of 10% filtered Na and delivers this isotonic fluid to the collecting ducts, which is able to remove only <5% of Na arriving. Hence, initially, with the loss of Na there is an increase in urine flow....this causes a dec in plasma vol; compensatorily thr is an increase overall in reabs of Na and therefore water from teh proximal tubules.
source ws kaplan; not sure whr in thr exactly. open to corrections...
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| sturge_weber
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wow good one , didnt know that
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