reet
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4 year old girld presents to ER in semi-comatose condition.Plasma GLUCOSE,UREA,GLUTAMINE are abnromally LOW; & LACTATE is normal.
On admission to ICU,where an increase in blood GLUCOSE was achieved by controlled INFUSION OF glucagon or alanine. which metabolic pathway is most likely deficient in child.?
A. hEPATIC GLUCONEOGENESIS
B. Skeletal muscle glycogenolysis
C. Adipose tissue lipolysis
D. Skeletal muscle proteolysis
E. Hepatic glycogenolysis.
plz ans with explaination....
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| roopashri
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D
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| reet
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yes u are right!!!! explain why D???
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| sturge_weber
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reet i too think its d
the hint is, that her urea and glutamine re abnormally low, and infusion of alanine leads to glucose production
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| msyamp
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The glucose-alanine cycle is used primarily as a mechanism for skeletal muscle to eliminate nitrogen while replenishing its energy supply. Glucose oxidation produces pyruvate which can undergo transamination to alanine. This reaction is catalyzed by alanine transaminase, ALT (ALT used to be referred to a serum glutamate-pyruvate transaminase, SGPT). Additionally, during periods of fasting, skeletal muscle protein is degraded for the energy value of the amino acid carbons and alanine is a major amino acid in protein. The alanine then enters the blood stream and is transported to the liver. Within the liver alanine is converted back to pyruvate which is then a source of carbon atoms for gluconeogenesis. The newly formed glucose can then enter the blood for delivery back to the muscle. The amino group transported from the muscle to the liver in the form of alanine is converted to urea in the urea cycle and excreted.
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| reet
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