Q NBME F2 S1

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Q NBME F2 S1

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4 Posts

vemi007
Forum Senior

Topics: 36
Posts: 74

11/26/05 - 06:29 PM

Tumor necrosis factor is the primary mediator of host responses initiated by LPS and leading to septic shock.LPS mediated activation of transcription most likely depends on which of the following transcription factors.

A) c-ras

B) Nuclear factor kappa B

C) p53

D) Rb Protein

E) VP-16 (etoposide)

Please provide answer along with the explanation.

msyamp
Forum Fanatic

Topics: 60
Posts: 1,462

11/26/05 - 06:43 PM

Nuclear factor -kB (NF-kB) is a ubiquitous transcription factor that is up-regulated in response to various stimuli, including LPS and TNFa. Its significance in septic shock can be highlighted by its activation in tissue following LPS treatment, and by the effect of its inhibition: selective inhibition of NF-kB in vivo, with pyrrolietine dithiocarbamate has been shown to reduce LPS-stimulated inducible NO synthesis and to prevent systemic hypotension associated with septic shock

Edited by msyamp on 11/26/05 - 06:56 PM

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vemi007
Forum Senior

Topics: 36
Posts: 74

11/26/05 - 07:09 PM

thanks for your answer, msyamp.

vemi007
Forum Senior

Topics: 36
Posts: 74

11/26/05 - 07:11 PM

msyamp, where can i find additional information about Nuclear factor -kB.

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