Question 01

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Question 01

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12 Posts

jonathon
Forum Senior

Topics: 25
Posts: 62

11/26/05 - 04:00 AM

A 12-year-old boy with hemophilia A has had episodes of pain about his knees for the past 6 years. Over time, there has been an increase in size of his knee joints, with deformity. Laboratory studies show decreased levels of coagulation factor VIII activity. Which of the following materials is most likely to be seen within the joint space following episodes of pain?

A Lipofuscin

B Russell bodies

C Neutrophils

D Cholesterol crystals

E Anthracotic pigment

shalu
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11/27/05 - 01:23 PM

is it "D"?

drk1980
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11/27/05 - 02:19 PM

morpheus
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11/27/05 - 08:11 PM

The answer, i think is D from the membranes of inflammatory cells.

robin082006
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11/27/05 - 11:38 PM

I think C: hemarthrosis--->acute inflammation---> neutrophil emigration.

Russel body: A small spherical intracytoplasmic hyaline body common in plasma cells in chronic inflammation

Anthracotic pigment: related to smoking and often exist in lung parenchyma

Cholesterol crystals: occasionally exist in rheumatoid arthritis

Lipofuscin: not relevant

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Shakeels
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11/27/05 - 11:46 PM

I think its C. Its hard question, like you can say every one can't be sure 100%.

dariush
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11/28/05 - 01:24 PM

i would go along with C.but the Q is not just a simple ACUTE inflammation. these ACUTE Bouts co-exist with a an already existing Chronic inflammation which has led to the deformity, namely calcification of the hematomas.

so B or D are not impossible!!

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sturge_weber
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11/28/05 - 03:15 PM

well what i can think of is , that episodes of pain re due to haemmorhage, so then there will be destrn of rbcs, hemosiderin, and then macrophages will engulf these, dont know if it co relates to neutrophils... i dont think so, but rest of the choicwes dont make any logic...

so i too go with c

just a confusion , what about lipofuscin, because it is a wear and tear pigment, and in the joint space is wear and tear, can it increase there as there is erosion of the joints

please clear my doubt, ........

sturge_weber
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11/29/05 - 10:46 AM

joanathan whats the answerr

reet
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11/29/05 - 11:10 AM

#10

i too go with c) neutrofils

bleeding into joints in hemphilia ...& 6 year of pain means some chronic infection +bouts of acute infection (neutrophils, macrophages are there) it can lead to formation of pre-inflamatory substances ...( OSTEOARTHRITIS.. later on)

Edited by reet on 11/29/05 - 11:39 AM

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demnat
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11/29/05 - 11:25 AM

#11

You would see neutrophils in acute infl.,not in chronic.maybe B?

reet
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11/29/05 - 11:41 AM

#12

so,,its like bouts of acute infection on chronic inflamation... may be C

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