robin082006
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patient comes to see you because he has been weak and falling down frequently. During the interview, you note that he is suspicious and irritable. On physical examination, you note that his skin is pale, his tarsal plates are pale, and he has a loss of vibration sense over his legs and trunk. His legs show a symmetric weakness with decreased deep tendon reflexes. The leading theory for the pathophysiology of this disorder relates to which of the following?
A. Anamolous insertion of even-chain fatty acids into membrane lipids
B. Anomalous insertion of odd-chain fatty acids into membrane lipids
C. Increased vitamin A intake
D. Lack of methylmalonyl CoA
E. Lack of propionyl CoA
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| cyra
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B
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| sturge_weber
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what sthe answer robbin
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| Doc2378
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D? (Vit B12 def leading to no conversion of propinyl CoA to methylmalonyl CoA...messed up Dorsal column and Lat corticospinal)...
Just guessing...
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| robin082006
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B is the correct ans
This is B12 deficiency. The body cannot metabolize odd fatty acid through Propionyl pathway, resulting in the accumulation of fatty acid.
In B12 deficiency, methylmalonyl CoA and propionyl CoA will increase, not decrease.
A and C are not relevant
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| sturge_weber
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good question
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| Doc2378
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___________________
Courage does not always ROAR. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow" - Mary Anne Radmacher
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| skyhigh
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what does b12 deficiency and accumulation of fatty acid have anything to do with the clinical presentation of the patient? anyone?....
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| sturge_weber
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methylmanoyl coa will accumulate and neurologic symptoms
the step is methyl malonyl coa to succinyl coa...
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