robin082006
Forum Hero
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A married couple is screened to assess the risk of Tay Sachs disease in their children. The activities of hexosaminidase A in the sera of Mother and Father are 45% and 55% respectively, of the reference value. The couple has one child. What is the probability of the child possessing one or more alleles of the Tay-Sachs mutation?
A) 0.0
B) 0.25
C) 0.5
D) 0.75
E) 1.0
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| roopashri
Forum Elite
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The hexosaminidase in mother and father are about half of the normal value. They should be the carriers of Tay Sach disease. The chance for the child to possess>=1 alleles (aa or Aa) is 75%
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| GMOB
Forum Elite
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I agree.
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| sturge_weber
Forum Guru
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yes 75% and the 45 and 55 re the variable expressivity
so while considering chance take it 50
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