drk1980
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Deficiency of B6 would inhibit which step in the TCA cycle?
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| drk1980
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this is a kaplan online simulated test question....anyone now?
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| sturge_weber
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well not sure but i think, only succinyl coa goes out from the tca cycle, into the heme synthesis, and heme synthesis is the one that is inhibited in pyridoxine deficiensy, hence succinyl coa to succinate will be affected, but not decreased, i think it will be increased...
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| Doc2378
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I agree
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| GMOB
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Well i think if the intermediaries acumulate, then acetylcoA wont enter the cycle, and therefore we wont have oxaloacetate going to citrate...The cycle is regulated by level of energy...????
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| sturge_weber
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hey gmob didnt get u, did u mean if the succinyl coa will increase more nadph will be produced, and hence this will inhibit the krebs cycle??????
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| GMOB
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Yes.
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| sturge_weber
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hey thanks man
gotcha
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| drk1980
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a def in B6 would lead to reduced activity of its enzyme...the transaminases.....which means the transfer of amino gp from one amino acid to form anthr amino acid will not take place efficiently....the amino acid invariably formed by this reaction is Alpha-ketoglutarate.
thr will be reduced synthesis of alpha-ketoglutarate wch just so happens to be- one of the intermediates of the TCA cycle!
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| skyhigh
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B6 deficiency also leads to accumulation of pyruvate in the muscle, and accumulation of oxaloacetate in liver,
and reduced synthesis of alanine and aspartate, respectively.
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| pocas
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B6 IS IMPORTANT FOR CISTHATIONE SYNTHASA SO IT COULDNT GO TO ALFA KETO BUTYRATE
B6 IS USED FOR ALA SYNTHASE INHIBATE FOR HEME
ANSWER IS FOR ALTER THE TRANSAMINASES SO ALTER ALFA KETOGLUTARATE
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