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Kaplan Qbank USMLE



Author10 Posts
  #1

13) A 58-year-old man with known hepatitis C and cirrhosis complains of worsening fatigue and confusion over the past 5 days. He has been admitted three times in the past 4 months for variceal bleeding and has had ascites that has been refractory to high-dose oral diuretic use. He also reports that over the past 48 hours he has had a declining urinary output. On physical examination, he is gaunt and jaundiced. He has tense ascites and a liver span of 7 cm in the midclavicular line. Laboratory results reveal a white blood cell count of 4600/mm3, a hemoglobin of 9.4 g/dL, and a hematocrit of 29%. His electrolytes reveal a BUN of 34 mg/dL and a creatinine of 3.1 mg/dL. A urinary sodium is less than 10 mEq/L. Which of the following is the most appropriate treatment for his elevated BUN and creatinine?

A. Large volume paracentesis
B. Hemodialysis
C. Mesocaval shunt
D. Kidney transplantation
E. Liver transplantation

  #2

B.

  #3

B. Hemodialysis

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  #4

B.

  #5

E. This patient with well advanced cirrhosis and portal hypertension has developed the onset of renal insufficiency consistent with hepatorenal syndrome. This occurs during the end stages of cirrhosis and is characterized by diminished urine output and low urinary sodium. In the setting of end-stage liver disease, renal vasoconstriction occurs, and the distal convoluted tubule responds by conserving sodium. Unless the renal function is allowed to deteriorate further, liver transplantation will reverse this vasoconstriction and kidney function will return to normal.

A large volume paracentesis (choice A) may relieve the ascites but will have no significant benefit on the impaired renal function.

There are no indications in this question to suggest that the patient requires acute hemodialysis (choice B).

A mesocaval shunt (choice C) is a surgical procedure that may decompress the portal pressure but will not have any benefit on renal function.

Renal transplantation (choice D) is of no value in this patient since the underlying lesion is in the liver; the kidneys will return to normal function if there is improvement in hepatic function.

  #6

phuluong2k wrote:
There are no indications in this question to suggest that the patient requires acute hemodialysis (choice B).


patient is confused and altered mental status is an indication for dialysis. I thought about hepatorenal and liver transplantation but chose dialysis as this is what is needed rite now. More over there is not enough data to reach the diagnosis of hepatorenal syndrom


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  #7

  • The diagnosis of HRS is one of exclusion and depends mainly on serum creatinine level, as no specific tests establish the diagnosis of HRS. Although serum creatinine level is a poor marker of renal function in patients with cirrhosis, no other validated and reliable noninvasive markers exist for monitoring renal function in these patients.

  • Diagnosis of HRS is based on the presence of a reduced GFR in the absence of other causes of renal failure in patients with chronic liver disease. The following criteria, as proposed by the International Ascites Club in 1996, help diagnose HRS:
    • Major criteria (All major criteria are required to diagnose HRS.)
        Low GFR, indicated by a serum creatinine level higher than 1.5 mg/dL or 24-hour creatinine clearance lower than 40 mL/min
        Absence of shock, ongoing bacterial infection and fluid losses, and current treatment with nephrotoxic medications

        No sustained improvement in renal function (decrease in serum creatinine to <1.5 mg/dL or increase in creatinine clearance to >40 mL/min) after diuretic withdrawal and expansion of plasma volume with 1.5 L of plasma expander

        Proteinuria less than 500 mg/d and no ultrasonographic evidence of obstructive uropathy or intrinsic parenchymal disease
    • Additional criteria (Additional criteria are not necessary for the diagnosis but provide supportive evidence.)
      • Urine volume less than 500 mL/d
        Urine sodium level less than 10 mEq/L

        Urine osmolality greater than plasma osmolality

        Urine red blood cell count of less than 50 per high-power field

        Serum sodium concentration greater than 130 mEq/L

      (courtsey emedicine.com)


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  #8

That was worth knowingnod

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  #9

pt's medicine history is not given in question tem, vitals r not there so we cant judge shock.urine osmolarity is not given, serum Na not given. sonographic findings not given, urine protein not given.....
thats why i sadi that there is not enough ground for diagnosis of HRS


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  #10

The scary part is, in the real exam there'll b even less relavent info given rolling eyes


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