usmlebuzz
Forum Elite
Topics: 93
Posts: 263
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how alpha-thallasemia presents first ?? ? :roll:
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| drnut
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Depends on the genotype:
1) Silent carrier: Clinical symptoms and physical findings are not present.
2) Homozygous alpha+ thalassemia (a-/a-) or heterozygous alpha0 thalassemia (--/aa): Clinical symptoms do not exist. This is diagnosed by incidental laboratory abnormalities (microcytosis) and family studies to characterize a relative.
3) Hemoglobin H disease (--/a-)
- Chronic hemolytic anemia
- Splenomegaly occurs by age 1 year, with progression to jaundice and hepatosplenomegaly.
- Skeletal changes due to expanded erythropoiesis in the marrow affect one third of patients.
4) Hemoglobin Barts or hydrops fetalis (--/--)
- Premature infant or death in utero
- Pallor
- Edematous friable placenta
- Massive hepatomegaly secondary to extramedullary hematopoiesis
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| usmlebuzz
Forum Elite
Topics: 93
Posts: 263
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thanks :lol:
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| zaki
Forum Guru
Topics: 92
Posts: 398
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presents with sign and symptoms of anemia
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Maverick
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