sing
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forgot why there is higher chance of kidney calcium oxalate stone in crohn's disease patients and anti freeze poisoned patients? could anybody explain? thanks a lot.
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| ARJ
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Short bowel syndrome. Short bowel syndrome, which may result from surgery in the small intestine, is marked by the inability of the intestines to absorb fat and nutrients properly (malabsorption). In such cases, calcium may bind to unabsorbed fat instead of to oxalates. This leaves excess oxalate, which is absorbed by the intestine and excreted into the kidney. People with Crohn's disease will have short bowel syndrome after resection.
antifreeze (ethylene glycol) ??????????? Forgot the mechanism.......
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| phuluong2k
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the metabolism product of antifreeze is oxalate
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| AAAAA
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ARJ,
Correct !
But it is the calcium that is not absorbed in the first part of the small intestine and bind to fat.
So there is no excessive oxalate but oxalate are selectively absorbed insted binding to the calcium the small intestine and secreted in the large gut instead of being absorbed !
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