nisha
lil monkey
Topics: 146
Posts: 919
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For those of you, who like me are ever confused:
What are the characteristics of transudative vs. exudative pleural effusions?
Exudative: pleural fluid [protein] / plasma [protein] > 0.5 and/or pleural fluid
[LDH] / plasma [LDH] > 0.6; transudative: neither of the above is true.
What underlying disorders are associated with transudative pleural effusions?
With exudative pleural effusions?
Transudative: transudates are ultrafiltrates of plasma with intact capillary
endothelial barrier – causes include CHF, end-stage liver disease, nephrotic
syndrome, protein-losing enteropathy, hypoproteinemia of any cause, superior
vena cava syndrome and glomerulonephritis; exudates occur when inflammation
leads to increased capillary permeability – causes include pneumonia
(parapneumonic effusion), malignancy, pulmonary tuberculosis, pancreatitis,
ovarian neoplasm (Meig's syndrome), collagen vascular disease (SLE, RA),
pulmonary infarction, intra-abdominal abscess, drug-induced and uremic pleuritis
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| winai
Forum Newbie
Topics: 0
Posts: 14
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hey nisha,
i have always doubt why LDH is used as the criteria? Whats the role of LDH outhere
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| nisha
lil monkey
Topics: 146
Posts: 919
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I really don't know..sorry 
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| frontal
Forum Guru
Topics: 53
Posts: 421
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Hey, if those ratios aren't true, bust the myth and tell us the ones that are!!
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| Renegade
Forum Elite
Topics: 18
Posts: 171
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winai wrote:
hey nisha,
i have always doubt why LDH is used as the criteria?
I'd imagine
-Easily measurable
-Present in significant amounts at all times
-Right size to diffuse in transudates and leak in exsudates
...as something to do with it 
I wouldn't be surprised if there were other molecules just as good, but prot and LDH are known for a long time.
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| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
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I have read an article about this
LDH is a cytoplasmic enzyme in almost every where, so it's location is inside the cell
If it's level is elevated in the plasma or extracellular fluid, that indicates cell death, or cell membrane injury etc, in all cases of exudates.
You are right renegade, there are also other molecules, but they are not used universally as LDH
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