paganini
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First, please try to write your question better the next time (My official language is spanish so it was difficult for me to read and understand your question).
The answer is tat.
This is because the main immune response to HIV consist of cytotoxic CD8+ lymphocytes. The Tat protein and Nef (a regulatory protein) repress the synthesis of class I MHC, this reduce the ability of citotoxic T celss to kill HIV-infected cells. Furthermore, mutations in any of the genes encoding class I MHC proteins result in more rapid progression to clinical AIDS. Also a person infected with a strain of HIV that has mutations in nef and Tat genes will be a long-term nonprogressor.
Vif enhances infectivity by inhibiting apobec3g(which causes hypermutations in HIV DNA) but not the main immune response (cytotoxic cd8+ lymphocytes)
pol and env genes arent regulatory genes, they are structural genes. Also are not related with long term nonprogressors resistance.
vpr is regulatory gene but again is not related with long term nonprogressors resistance. Want to know what it does? go and read micro book...
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| trevor
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WELL THANX PAGANINI 4 YR ADVICE (ALTHOUGH I THINK THERE IS NO GROSS PROB WITH THE LANGUAGE OF THE Q)
I AGREE WIYH YR ANS. ACTUALLY I PICKED D Q FROM KAPLAN MICRO NOTES . THE ANS THERE WAS "POL".
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| usmlegr
Forum Junior
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pol is not a regulatory gene, pol is a structural gene. Why does it say in Kaplan that it's pol?
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| paganini
Forum Senior
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Well Trevor you should not confuse people in this forum. After you said that you picked your question from kaplan I went to kaplan's microbiology book and found your question there and the answer was tat, just like i told you, but they gave another explanation (not a very clear one). So dont say that kaplan's book says pol in the answer.
I actually forgot to say that tat gene codes for a protein(tat protein) which function in the activation of transcription of viral genes and that also explain why tat is the correct answer.
For anyone who have kaplan's book (2004 edition) go to page 190 and you'll find the question; on page 197 there is the answer.
For those who don't have kaplan's book, here is the question and answer from the book:
4. Two individuals become infected with HIV at approximately the same time. JT progresses rapidly to full-blown AIDS and dies within 3 years. AY is still asymptomatic after 10 years. One possible explanation is that the virus in JT is probably expressing a high amount of activity of wich regulatory gene product?
A. vif
B. vpr
C. tat
D. env
E. pol
Answer: C. Products of tat and rev genes increase viral maturation and act to decrease the latent period (J.T. probably had a high expresion of those genes). The vif gene product affects viral infectivity, and vpr gene products increase the effeciency of of budding. Another possible difference is that A.Y. may lack the invasion gene, which codes a cellular co-receptor or HIV. Env codes for envelope antigen and pol codes for reverse transcriptase.
To usmlegr: you are right, as I said in the anterior post, pol is a structural gene.
To moderators: I dont know if is illegal to copy a question from a book and post it here, please i would like to know.
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| usmlegr
Forum Junior
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thank you paganini for your precise answer!
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| trevor
Forum Junior
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well i have an older edition of kaplan where d is the ans. q on page 688 and ans on page695
well i must say u r smart paganini but a little bit "over"
good luck to u
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| bactitech
Forum Elite
Topics: 25
Posts: 496
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I must say that I agree with paganini on the wording of the question. I have worked in hospitals for 30 years. Communication problems breed errors. Hospitals are BIG into error reduction nowadays, due to big press coverage of these problems. Internet shorthand, non-use of capitalization, and phonetic spellings can cause HUGE problems in hospital charting and recording of information. While cute when you're instant messaging, Trevor, this type of communication will NOT work when you're writing orders on charts. Everything must be precise or you will get LOTS of calls from nurses and the lab to clarify your orders, and your head resident will not be pleased.
I don't mean to get on a soap box - then again maybe I do. I think the internet is a great way of communicating, but IM and TEXT messaging are shortcuts that just won't be able to work in a healthcare setting. There are certain abbreviations now that are NOT allowed on charts, and most hospitals are going to paperless charting in the next few years. This is not the same as talking with your friends on the 'net, I'm afraid.
I know you kids are smart because you never would have gotten into med school if you weren't. However, when you write
2 individuals becum infected with hiv at approx same time. jt progresses to aide and dies in 3 yrs.ay still asymptomatic after 10 yrs. jt expressing high amount of activity of which regulatory gene product?
which I assume says:
Two individuals become infected with HIV at approximately the same time. JT [what is this - I have no clue] progresses to AIDS and dies in 3 years. Ay [what is this??? who is this???] still asymptomatic after 10 years. JT [again I'm clueless] expressing high amount of activity of which regulatory gene product?
In re-reading the question, I'm assuming JT is one patient, and AY is another? Please help me out here.
Your spelling and punctuation really need to express how intelligent you are. Otherwise it seems as if you're just shuffling around with your wording. I know you guys had stellar grades and MCAT results; you or your parents have paid thousands of dollars in tuition to even get you to this point. Your grammar must reflect that. Many docs communicate via email now. If I got that email from my doctor I would be extremely upset.
You will have many age groups represented in your patient load, along with many ethnicities and cultures represented. Precise communication is the way to go, and you'll never get into trouble if you re-read what you write before posting.
End of mom lecture......
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| paganini
Forum Senior
Topics: 26
Posts: 159
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To bactitech: thanks a lot for your comments and advices.
To Trevor: I wanted to help you with this question. Nothing else...
"Press on. Nothing can take the place of persistence. Talent will not; the world is full of unsuccessful people with talent. Genius will not; unrewarded genius is almost a proverb. Education alone will not; the world is full of educated derelicts. Persistence and determination alone are omnipotent."
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| trevor
Forum Junior
Topics: 7
Posts: 21
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hey guys lets get over with it. we have so many other things to discuss
thanks bactitech for your post. ill surely keep it in mind
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| trevor
Forum Junior
Topics: 7
Posts: 21
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good luck
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